Pneumococcal antibody concentrations of subjects in communities fully or partially vaccinated with a seven-valent pneumococcal conjugate vaccine.


Ota, MO; Roca, A; Bottomley, C; Hill, PC; Egere, U; Greenwood, B; Adegbola, RA; (2012) Pneumococcal antibody concentrations of subjects in communities fully or partially vaccinated with a seven-valent pneumococcal conjugate vaccine. PLoS One, 7 (8). e42997. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0042997

[img]
Preview
Text - Published Version
License:

Download (787kB) | Preview

Abstract

BACKGROUND A recent trial with PCV-7 in a rural Gambian community showed reduced vaccine-type pneumococcal carriage in fully vaccinated compared with control communities. We measured pneumococcal polysaccharide antibody concentrations in this trial to understand further the mechanisms underlying the observed changes. METHODS A single-blind, cluster-randomized (by village) trial was conducted in 21 Gambian villages. In 11 villages, all residents received PCV-7 (Vaccine group); in 10 control villages only children <30 months old or those born during the study received PCV-7. Subjects over the age of 30 months resident in vaccine villages received a single dose of PCV-7 whilst those in control villages received a single dose of a serogroup C meningococcal conjugate vaccine. Serum antibody concentrations against specific pneumococcal polysaccharides were measured in approximately 200 age-stratified subjects before, 4-6, 12 and 24 months following vaccination. RESULTS Baseline pneumococcal antibody concentrations were generally high and increased with age up to 10 years. One dose of PCV-7 increased geometric mean antibody concentrations (GMC) in vaccinated versus control villages for vaccine serotypes 6B and 18C, and 4 and 18C, in the young (under 5 years) and older age groups (5+ years) respectively. There were significantly higher proportions of subjects in the vaccinated than in the control communities with an antibody concentration believed to protect against carriage (>5.0 µg/mL) for all but serotype 9V of the PCV-7 serotypes in the older group, but not in the younger age group. CONCLUSION Higher antibodies in vaccinated communities provide an explanation for the lower pneumococcal carriage rates in fully vaccinated compared to control communities. TRIAL REGISTRATION Controlled-Trials.com ISRCTN51695599 51695599.

Item Type: Article
Keywords: Adolescent, Antibodies, Bacterial, blood, Child, Child, Preschool, Humans, Pneumococcal Infections, immunology, prevention & control, Pneumococcal Vaccines, administration & dosage, immunology, Vaccines, Conjugate, administration & dosage, immunology, ARRAY(0xc9346fc), ARRAY(0xd7ae5e0), ARRAY(0xd3723b4), ARRAY(0xccd2fbc), ARRAY(0xd98e4e8), ARRAY(0xc7e775c), ARRAY(0xb7f536c4), ARRAY(0xe1dc6b8), ARRAY(0xe5109c8), ARRAY(0xe0d5e90), ARRAY(0x8b15b98)
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
Tropical Epidemiology Group
PubMed ID: 22916192
Web of Science ID: 307500800036
URI: http://researchonline.lshtm.ac.uk/id/eprint/612383

Statistics


Download activity - last 12 months
Downloads since deposit
172Downloads
343Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item