Cure by age and stage at diagnosis for colorectal cancer patients in North West England, 1997-2004: A population-based study


Shack, LG; Shah, A; Lambert, PC; Rachet, B; (2012) Cure by age and stage at diagnosis for colorectal cancer patients in North West England, 1997-2004: A population-based study. Cancer epidemiology, 36 (6). pp. 548-553. ISSN 1877-7821 DOI: 10.1016/j.canep.2012.06.011

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Abstract

Background: Stage and age at diagnosis are important prognostic factors for patients with colorectal cancer. However, the proportion cured by stage and age is unknown in England. Materials and methods: This population-based study includes 29,563 adult patients who were diagnosed and registered with colorectal cancer during 1997-2004 and followed till 2007 in North West England. Multiple imputation was used to provide more reliable estimates of stage at diagnosis, when these data were missing. Cure mixture models were used to estimate the proportion 'cured' and the median survival of the uncured by age and stage. Results: For both colon and rectal cancer the proportion of patients cured and median survival time of the uncured decreased with advancing stage and increasing age. Patients aged under 65 years had the highest proportion cured and longest median survival of the uncured. Conclusion: Cure of colorectal cancer patients is dependent on stage and age at diagnosis with younger patients or those with less advanced disease having a better prognosis. Further efforts are required, in order to reduce the proportion of patients presenting with stage III and IV disease and ultimately increase the chance of cure. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Cancer Survival Group
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 22819236
Web of Science ID: 312260900020
URI: http://researchonline.lshtm.ac.uk/id/eprint/612359

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