Growth Inhibition of Pathogenic Bacteria by Sulfonylurea Herbicides.


Kreisberg, JF; Ong, NT; Krishna, A; Joseph, TL; Wang, J; Ong, C; Ooi, HA; Sung, JC; Siew, CC; Chang, GC; Biot, F; Cuccui, J; Wren, BW; Chan, J; Sivalingam, SP; Zhang, LH; Verma, C; Tan, P; (2013) Growth Inhibition of Pathogenic Bacteria by Sulfonylurea Herbicides. Antimicrobial agents and chemotherapy, 57 (3). pp. 1513-7. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02327-12

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Abstract

: Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 23263008
Web of Science ID: 314968100054
URI: http://researchonline.lshtm.ac.uk/id/eprint/612323

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