The natural progression of gambiense sleeping sickness: what is the evidence?


Checchi, F; Filipe, JA; Barrett, MP; Chandramohan, D; (2008) The natural progression of gambiense sleeping sickness: what is the evidence? PLoS neglected tropical diseases, 2 (12). e303. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0000303

[img]
Preview
Text - Published Version
License:

Download (251kB) | Preview

Abstract

Gambiense human African trypanosomiasis (HAT, sleeping sickness) is widely assumed to be 100% pathogenic and fatal. However, reports to the contrary exist, and human trypano-tolerance has been postulated. Furthermore, there is uncertainty about the actual duration of both stage 1 and stage 2 infection, particularly with respect to how long a patient remains infectious. Understanding such basic parameters of HAT infection is essential for optimising control strategies based on case detection. We considered the potential existence and relevance of human trypano-tolerance, and explored the duration of infectiousness, through a review of published evidence on the natural progression of gambiense HAT in the absence of treatment, and biological considerations. Published reports indicate that most gambiense HAT cases are fatal if untreated. Self-resolving and asymptomatic chronic infections probably constitute a minority if they do indeed exist. Chronic carriage, however, deserves further study, as it could seed renewed epidemics after control programmes cease.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: ECOHOST - The Centre for Health and Social Change
PubMed ID: 19104656
Web of Science ID: 263301000001
URI: http://researchonline.lshtm.ac.uk/id/eprint/6099

Statistics


Download activity - last 12 months
Downloads since deposit
205Downloads
293Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item