Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men: The Caerphilly Prospective Study.


Bolton, CE; Cockcroft, JR; Sabit, R; Munnery, M; McEniery, CM; Wilkinson, IB; Ebrahim, S; Gallacher, JE; Shale, DJ; Ben-Shlomo, Y; (2009) Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men: The Caerphilly Prospective Study. International journal of epidemiology, 38 (3). pp. 867-76. ISSN 0300-5771 DOI: https://doi.org/10.1093/ije/dyn374

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Abstract

BACKGROUND: Increased arterial stiffness predicts future cardiovascular disease and in some cross-sectional studies it is related to worse lung function and obstructive pulmonary disease. We assessed the predictive value of lung function measured in mid-life as compared with later life on arterial stiffness in the Caerphilly Prospective Study (CaPS). METHODS: Men aged 47-67 years had lung function measured between 1984 and 1988 and repeated between 2002 and 2004 (n = 827) as well as having carotid-femoral pulse wave velocity (PWV) measured. RESULTS: Both forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC) in mid-life and later life were inversely associated with PWV (P < 0.0001) but mid-life measures were stronger predictors. Only mid-life measures remained predictors after mutual adjustment (FEV(1) mid-life beta coeff. -0.65, 95% CI -1.04, -0.26, P < 0.0001; FVC mid-life beta coeff. -0.52, 95% CI -0.82, -0.23, P < 0.0001). Adjustment for smoking status, early life, inflammatory and metabolic factors in sub-groups did not markedly change the associations. CONCLUSIONS: Mid-life lung function is a stronger risk factor than in later life for arterial stiffness in men. It is possible that developmental factors influence both lung function and arterial stiffness. Lung function assessment in mid-life may identify individuals at greater risk of their future cardiovascular disease.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 19204008
Web of Science ID: 268810100036
URI: http://researchonline.lshtm.ac.uk/id/eprint/5917

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