Prospective study of circulating soluble CD40 Ligand concentrations and incident CVD in a nested prospective case-control study of older men and women.


Jefferis, BJ; Whincup, PH; Welsh, P; Wannamethee, SG; Rumley, A; Lawlor, DA; Ebrahim, S; Lowe, GD; (2011) Prospective study of circulating soluble CD40 Ligand concentrations and incident CVD in a nested prospective case-control study of older men and women. Journal of thrombosis and haemostasis. ISSN 1538-7933 DOI: https://doi.org/10.1111/j.1538-7836.2011.04415.x

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Abstract

Background: CD40L is implicated in atherosclerotic plaque formation. Objectives: We investigate prospective associations between circulating soluble CD40L and MI or stroke in an older general population cohort, accounting for established and novel cardiovascular risk factors. Methods: Baseline serum sCD40L was measured in incident MI (n=368) and stroke (n=304) cases and 2 controls per case, 'nested' in prospective UK studies of 4252 men and 4286 women aged 60-79 years, sampled from general practices in Britain in 1998-2000, with 7-year follow-up for fatal and non-fatal MI and stroke. Results: Serum sCD40L was higher in smokers and negatively associated with lung function and positively associated with total cholesterol and markers of inflammation, but not with other established CVD risk factors. Geometric mean sCD40L levels did not differ between MI cases and controls (6.28 pg/mL versus 6.09 pg/mL; p=0.5) or between stroke cases and controls (5.93 pg/mL versus 5.55 pg/mL, p = 0.1). There was no strong evidence for elevated risk of MI or stroke in multivariable models comparing participants in the top to those in the bottom third of sCD40L. Age-adjusted odds ratios were 1.39(95%CI 0.98, 1.96) for MI and 1.16 (0.78, 1.73) for stroke. These attenuated to1.24 (95%CI 0.86, 1.79) and 1.18 (0.78, 1.78), respectively, after adjustment for established and novel CVD risk factors. Conclusions: Serum sCD40L is associated with other inflammatory markers but is not itself a strong independent risk marker for either stroke or MI.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 21696538
Web of Science ID: 293791400002
URI: http://researchonline.lshtm.ac.uk/id/eprint/582

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