First generation leishmaniasis vaccines: A review of field efficacy trials


Noazin, S; Modabber, F; Khamesipour, A; Smith, PG; Moulton, LH; Nasseri, K; Sharifi, I; Khalil, EAG; Bernal, IDV; Antunes, CMF; Kieny, MP; Tanner, M; (2008) First generation leishmaniasis vaccines: A review of field efficacy trials. Vaccine, 26 (52). pp. 6759-6767. ISSN 0264-410X DOI: 10.1016/j.vaccine.2008.09.085

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Abstract

First generation candidate vaccines against leishmaniasis, prepared using inactivated whole parasites as their main ingredient, were considered as promising because of their relative ease of production and low cost. These vaccines have been the subject of many investigations over several decades and are the only leishmaniasis vaccine candidates which have undergone phase 3 clinical trial evaluation. Although the studies demonstrated the safety of the vaccines and several studies showed reasonable immunogenicity and some indication of protection, an efficacious prophylactic vaccine is yet to be identified. Despite this overall failure, these trials contributed significantly to increasing knowledge on human leishmaniasis immunology. To provide a collective view, this review discusses the methods and findings of field efficacy trials of first generation leishmaniasis vaccine clinical trials conducted in the Old and New Worlds. (C) 2008 Elsevier Ltd. All rights reserved.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Leishmaniasis Group
Centre for Global Non-Communicable Diseases (NCDs)
Neglected Tropical Diseases Network
Tropical Epidemiology Group
Vaccine Centre
PubMed ID: 18950671
Web of Science ID: 261898400008
URI: http://researchonline.lshtm.ac.uk/id/eprint/5799

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