Burkholderia pseudomallei: animal models of infection.


Titball, RW; Russell, P; Cuccui, J; Easton, A; Haque, A; Atkins, T; Sarkar-Tyson, M; Harley, V; Wren, B; Bancroft, GJ; (2008) Burkholderia pseudomallei: animal models of infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 Suppl 1. S111-6. ISSN 0035-9203 DOI: 10.1016/S0035-9203(08)70026-9

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Abstract

A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease. In mice, and depending on the route of infection, dose, and mouse strain, the disease can range from a chronic, and in some cases, an apparently latent infection to an acute fulminant disease. Alternative small animal models of infection include diabetic rats or hamsters. Larger animal models of disease have not yet been fully developed. It is not clear which of the small animal models of melioidosis most accurately reflect disease in humans. However, the findings that diabetic rats are susceptible to infection, that some strains of mice can develop persistent subclinical infections that can spontaneously reactivate, and that inhalation exposure generally results in more acute disease suggest that these different models mimic different aspects of human melioidosis.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 19121670
URI: http://researchonline.lshtm.ac.uk/id/eprint/5741

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