Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons.


Islami, F; Boffetta, P; van Schooten, FJ; Strickland, P; Phillips, DH; Pourshams, A; Fazel-Tabar Malekshah, A; Godschalk, R; Jafari, E; Etemadi, A; Abubaker, S; Kamangar, F; Straif, K; Møller, H; Schüz, J; Malekzadeh, R; (2012) Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons. Front Oncol, 2. p. 14. ISSN 2234-943X DOI: https://doi.org/10.3389/fonc.2012.00014

[img]
Preview
Text - Published Version
License:

Download (371kB) | Preview

Abstract

: Studies have suggested a possible role of polycyclic aromatic hydrocarbons (PAHs) in the etiology of esophageal cancer in Golestan Province, Iran, where incidence of this cancer is very high. In order to investigate the patterns of non-smoking related exposure to PAHs in Golestan, we conducted a cross-sectional study collecting questionnaire data, genotyping polymorphisms related to PAH metabolism, and measuring levels of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite, in urine samples collected in two seasons from the same group of 111 randomly selected never-smoking women. Beta-coefficients for correlations between 1-OHPG as dependent variable and other variables were calculated using linear regression models. The creatinine-adjusted 1-OHPG levels in both winter and summer samples were approximately 110??mol/molCr (P for seasonal difference?=?0.40). In winter, red meat intake (??=?0.208; P?=?0.03), processed meat intake (??=?0.218; P?=?0.02), and GSTT1-02 polymorphism ("null" genotype: ??=?0.228; P?=?0.02) showed associations with 1-OHPG levels, while CYP1B1-07 polymorphism (GG versus AA?+?GA genotypes: ??=?-0.256; P?=?0.008) showed an inverse association. In summer, making bread at home (> weekly versus never: ??=?0.203; P?=?0.04), second-hand smoke (exposure to ?3 cigarettes versus no exposure: ??=?0.254; P?=?0.01), and GSTM1-02 "null" genotype (??=?0.198; P?=?0.04) showed associations with 1-OHPG levels, but GSTP1-02 polymorphism (CT?+?TT versus CC: ??=?-0.218; P?=?0.03) showed an inverse association. This study confirms high exposure of the general population in Golestan to PAHs and suggests that certain foods, cooking methods, and genetic polymorphisms increase exposure to PAHs.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 22655262
URI: http://researchonline.lshtm.ac.uk/id/eprint/56926

Statistics


Download activity - last 12 months
Downloads since deposit
372Downloads
264Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item