Radiation-attenuated schistosome vaccination - a brief historical perspective.

Bickle, QD; (2009) Radiation-attenuated schistosome vaccination - a brief historical perspective. Parasitology, 136 (12). pp. 1621-32. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182009005848

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The high level of protection which can be induced by vaccination of a range of hosts, from rodents to primates, with live radiation-attenuated schistosome larvae offers great promise for development of a human schistosome vaccine. Studies of the irradiated vaccine models benefitted from significant funding during the 1970-90s and much was learned concerning the inducers, targets and mechanisms of immunity. Less progress was made in definition of the protective antigens involved. The application of new techniques for identifying membrane and secreted antigens has recently provided new vaccine candidates and a new impetus for schistosome vaccine development. This article is intended as an overview of some of the main lessons learned from the studies of the irradiated vaccines as a backdrop to renewed interest in schistosome vaccine development.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 19327194
Web of Science ID: 270207900023
URI: http://researchonline.lshtm.ac.uk/id/eprint/5660


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