HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi.


Houben, RM; Crampin, AC; Mallard, K; Mwaungulu, JN; Yates, MD; Mwaungulu, FD; Ngwira, BM; French, N; Fine, PE; Glynn, JR; (2009) HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103 (12). pp. 1187-9. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2009.03.013

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Abstract

Tuberculosis (TB) patients with strains common to other recent cases ('clustering') suggest recent transmission. HIV status and age may affect proportions clustered. We investigated TB clustering by HIV and age in a population-based study in Malawi. Among 746 patients, HIV infection increased the proportion clustered. Sex-period-adjusted odds ratios for the association of HIV and clustering were 1.26 (95% CI 0.4-4.1) for ages 15-25 years, 1.40 (0.9-2.3) for 25-50 years and 10.44 (2.3-47.9) for >50 years and remained stable over two periods examined. These results suggest that HIV increases the proportion of TB due to recent transmission in the elderly.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: MEIRU
TB Centre
PubMed ID: 19362727
Web of Science ID: 272648500001
URI: http://researchonline.lshtm.ac.uk/id/eprint/5659

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