A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone


Sapkota, BR; Shrestha, K; Pandey, B; Walker, SL; (2008) A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone. Leprosy review, 79 (4). pp. 425-8. ISSN 0305-7518

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Abstract

: Dapsone Hypersensitivity Syndrome (DHS) occurs in approximately 2% of leprosy patients in Nepal. DHS and other adverse effects of dapsone lead to withdrawal of the drug.<br/> : We reviewed the notes of patients who had dapsone withdrawn from their multi-drug therapy (MDT) following an adverse reaction to the drug between 1990 and 2007.<br/> : 105 patients were identified from the database and 67 had a documented completion of a modified course of MDT. The majority were treated with rifampicin and clofazimine. All 36 individuals who were slit-skin smear positive had a satisfactory fall in their mean bacterial index. There were no cases of relapse.<br/> : Rifampicin and clofazimine appear to be satisfactory treatment for both paucibacillary and multibacillary patients who have to have dapsone stopped because of severe adverse effects.<br/>

Item Type: Article
Keywords: Adolescent, Adult, Aged, Clofazimine, administration & dosage, adverse effects, therapeutic use, Dapsone, administration & dosage, adverse effects, therapeutic use, Drug Therapy, Combination, Female, Humans, Leprostatic Agents, administration & dosage, adverse effects, therapeutic use, Leprosy, drug therapy, epidemiology, pathology, Male, Middle Aged, Nepal, epidemiology, Retrospective Studies, Rifampin, administration & dosage, adverse effects, therapeutic use, Treatment Outcome
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 19274989
Web of Science ID: 263710300010
URI: http://researchonline.lshtm.ac.uk/id/eprint/5615

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