Surface antigens of Plasmodium falciparum gametocytes--a new class of transmission-blocking vaccine targets?


Sutherland, CJ; (2009) Surface antigens of Plasmodium falciparum gametocytes--a new class of transmission-blocking vaccine targets? Molecular and biochemical parasitology, 166 (2). pp. 93-8. ISSN 0166-6851 DOI: 10.1016/j.molbiopara.2009.03.007

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Abstract

The re-establishment of elimination and eradication on the malaria control agenda has led to calls for renewed effort in the development of parasite transmission-blocking interventions. Vaccines are ideally suited to this task, but progress towards an anti-gamete transmission-blocking vaccine, designed to act on parasites in blood-fed mosquitoes, has been slow. Recent work has confirmed that the surface of the gametocyte-infected erythrocyte presents antigens to the host immune system, and elicits specific humoral immune responses to these antigens, termed gametocyte surface antigens (GSAs). Likely candidate molecules, including antigens encoded by sub-telomeric multi-gene families, are discussed, and a hypothetical group of parasite molecules involved in spatial and temporal signal transduction in the human host is proposed, the tropins and circadins. The next steps for development of anti-gametocyte transmission-blocking vaccines for P. falciparum and the other human malaria species are considered.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
Vaccine Centre
PubMed ID: 19450726
Web of Science ID: 266997300001
URI: http://researchonline.lshtm.ac.uk/id/eprint/5406

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