Importance of Allergy in Asthma: An Epidemiologic Perspective


Douwes, J; Brooks, C; van Dalen, C; Pearce, N; (2011) Importance of Allergy in Asthma: An Epidemiologic Perspective. Current allergy and asthma reports, 11 (5). pp. 434-444. ISSN 1529-7322 DOI: https://doi.org/10.1007/s11882-011-0215-6

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Abstract

There has been a global epidemic of asthma during the past half-century. More recently, the prevalence has leveled off or declined in many Western countries, whereas the prevalence in less affluent nations is still increasing. The reasons for this and the different geographical patterns of asthma prevalence remain unclear. This paper provides an epidemiologic perspective on whether allergen exposure and allergies can explain these trends. In particular, the paper discusses 1) geographical and temporal trends in asthma and the role of allergens and allergy, 2) the importance of nonallergic mechanisms, 3) nonallergenic exposures that may modify the risk of allergies and asthma, and 4) new and emerging risk and protective factors. Although allergy and asthma are closely related, allergen exposure and allergy alone cannot explain current time trends and geographical patterns of asthma. Population-based studies focusing on recently identified risk and protective factors may provide further insight.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 21792637
Web of Science ID: 294467000014
URI: http://researchonline.lshtm.ac.uk/id/eprint/54

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