Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study

Rake, C; Gilham, C; Hatch, J; Darnton, A; Hodgson, J; Peto, J; (2009) Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study. British journal of cancer, 100 (7). pp. 1175-1183. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6604879

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We obtained lifetime occupational and residential histories by telephone interview with 622 mesothelioma patients (512 men, 110 women) and 1420 population controls. Odds ratios (ORs) were converted to lifetime risk (LR) estimates for Britons born in the 1940s. Male ORs (95% confidence interval (Cl)) relative to low-risk occupations for > 10 years of exposure before the age of 30 years were 50.0 (25.8-96.8) for carpenters (LR 1 in 17), 17.1 (10.3-28.3) for plumbers, electricians and painters, 7.0 (3.2-15.2) for other construction workers, 15.3 (9.0-26.2) for other recognised high-risk occupations and 5.2 (3.1-8.5) in other industries where asbestos may be encountered. The LR was similar in apparently unexposed men and women (similar to 1 in 1000), and this was approximately doubled in exposed workers' relatives (OR 2.0, 95% Cl 1.3-3.2). No other environmental hazards were identified. In all, 14% of male and 62% of female cases were not attributable to occupational or domestic asbestos exposure. Approximately half of the male cases were construction workers, and only four had worked for more than 5 years in asbestos product manufacture. British Journal of Cancer (2009) 100, 1175-1183. doi: 10.1038/sj.bjc.6604879 www.bjcancer.com

Item Type: Article
Keywords: Adult, Aged, Asbestos, adverse effects, Asbestos, Amosite, adverse effects, Case-Control Studies, Environmental Exposure, adverse effects, Female, Humans, Male, Mesothelioma, etiology, mortality, Middle Aged, Occupational Exposure, adverse effects, Odds Ratio, Risk
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 19259084
Web of Science ID: 264747700021
URI: http://researchonline.lshtm.ac.uk/id/eprint/5311


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