Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET)


Bulpitt, CJ; Beckett, NS; Peters, R; Banya, W; Liu, LS; Wang, JG; Stoyanovsky, V; Dumitrascu, D; Nikitin, Y; Staessen, JA; Burch, L; Fletcher, AE; (2009) Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET). Blood pressure, 18 (1-2). pp. 17-22. ISSN 0803-7051 DOI: https://doi.org/10.1080/08037050902836779

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Abstract

The Hypertension in the Very Elderly Trial (HYVET) is a randomized double-blind trial of active antihypertensive treatment (indapamide 1.5 mg sustained release 24 mg perindopril) vs placebo in participants over the age of 80 years with a systolic blood pressure (SBP) of 160-199 mmHg during a placebo run-in period plus a diastolic blood pressure (DBP) of110 mmHg. The trial has completed with 3845 subjects randomized and we report the baseline characteristics. The participants were a healthy group. The numbers smoking, drinking alcohol and having previous cardiovascular events were low, and their hypertensive status was not usually associated with the metabolic syndrome; 1.0% of the whole group had a total cholesterol over 8.0 mmol/l, 1.1% a blood sugar over 11.1 mmol/l (irrespective of anti-diabetic treatment) and 1.7% a serum urate over 460 mol/l (women) and 0.6% over 520 mol/l (men). A serum creatinine over 150 mol/l excluded participants from the trial. The gender differences and age comparisons were as expected but the women had higher average total and high-density-lipoprotein-cholesterol blood concentrations. Those with prior cardiovascular disease had an excess of the known cardiovascular risk factors. The baseline characteristics provide a basis for further understanding of the HYVET results, which have been published recently.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 19353407
Web of Science ID: 265291000003
URI: http://researchonline.lshtm.ac.uk/id/eprint/5293

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