Treatment of neurocysticercosis: current status and future research needs


Nash, TE; Singh, G; White, AC; Rajshekhar, V; Loeb, JA; Proano, JV; Takayanagui, OM; Gonzalez, AE; Butman, JA; Degiorgio, C; del Brutto, OH; Delgado-Escueta, A; Evans, CA; Gilman, RH; Martinez, SM; Medina, MT; Pretell, EJ; Teale, J; Garcia, HH; (2006) Treatment of neurocysticercosis: current status and future research needs. Neurology, 67 (7). pp. 1120-7. ISSN 0028-3878 DOI: https://doi.org/10.1212/01.wnl.0000238514.51747.3a

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Abstract

Here we put forward a roadmap that summarizes important questions that need to be answered to determine more effective and safer treatments. A key concept in management of neurocysticercosis is the understanding that infection and disease due to neurocysticercosis are variable and thus different clinical approaches and treatments are required. Despite recent advances, treatments remain either suboptimal or based on poorly controlled or anecdotal experience. A better understanding of basic pathophysiologic mechanisms including parasite survival and evolution, nature of the inflammatory response, and the genesis of seizures, epilepsy, and mechanisms of anthelmintic action should lead to improved therapies.

Item Type: Article
Keywords: Anticonvulsants/*therapeutic use, Antiplatyhelmintic Agents/*therapeutic use, Biomedical Research/*trends, Forecasting, Humans, Needs Assessment, Neurocysticercosis/*diagnosis/*therapy, Neurosurgical Procedures/*methods, Physician's Practice Patterns/*trends, Practice Guidelines as Topic
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 17030744
Web of Science ID: 241077100004
URI: http://researchonline.lshtm.ac.uk/id/eprint/5223

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