Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru


Mayta, H; Gilman, RH; Arenas, F; Valencia, T; Caviedes, L; Montenegro, SH; Ticona, E; Ortiz, J; Chumpitaz, R; Evans, CA; Williams, DL; (2003) Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru. Journal of clinical microbiology, 41 (12). pp. 5774-7. ISSN 0095-1137 DOI: https://doi.org/10.1128/JCM.41.12.5774-5777.2003

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Abstract

Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.

Item Type: Article
Keywords: Antitubercular Agents/pharmacology/therapeutic use, DNA-Directed RNA Polymerases/genetics, Drug Resistance, Multiple/*genetics, Humans, Microbial Sensitivity Tests, Mycobacterium tuberculosis/drug effects/*genetics/isolation & purification, Peru, Polymerase Chain Reaction/*methods, Predictive Value of Tests, Rifampin/pharmacology/therapeutic use, Sensitivity and Specificity, Tuberculosis/drug therapy
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 14662980
Web of Science ID: 187228800070
URI: http://researchonline.lshtm.ac.uk/id/eprint/5216

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