On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity


Guzzetta, G; Manfredi, P; Gasparini, R; Panatto, D; Edmunds, WJ; (2009) On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity. Vaccine, 27 (25-26). pp. 3429-3434. ISSN 0264-410X DOI: 10.1016/j.vaccine.2009.01.092

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Abstract

We consider a model for the transmission dynamics of Neisseria meningitidis which incorporates the humoral immunity hypothesis in an explicit way. The "humoral immunity" hypothesis states that individuals will experience significantly different risks of invasive disease depending oil whether they are experiencing their first infection episode, or a subsequent one. The model is fitted to the Stonehouse-Danbury carriage data and to UK disease data. For serogroup C (B) the risk of disease during the first infection episode results to be 100 (400) times higher compared to subsequent ones. Moreover the best-fit corresponds to the situation where N. lactamica essentially always confers cross-protection. (c) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 19460601
Web of Science ID: 266947900035
URI: http://researchonline.lshtm.ac.uk/id/eprint/5162

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