Prospective study of IL-18 and risk of MI and stroke in men and women aged 60-79years: A nested case-control study.


Jefferis, BJ; Whincup, PH; Welsh, P; Wannamethee, SG; Rumley, A; Ebrahim, S; Lawlor, DA; Lowe, GD; (2012) Prospective study of IL-18 and risk of MI and stroke in men and women aged 60-79years: A nested case-control study. Cytokine. ISSN 1043-4666 DOI: https://doi.org/10.1016/j.cyto.2012.10.010

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Abstract

: AIM: IL-18 is hypothesized to destabilise atherosclerotic plaques, leading to thrombotic events and epidemiologic studies suggest that IL-18 may increase risk of CHD or CVD. We examined prospective associations between levels of serum IL-18 and new CHD and stroke events in older men and women from a general population. METHODS: A case-control study was nested within a prospective cohort of men and women aged 60-79years recruited from general practices in 25 British towns in 1998-2000 and followed-up for 7.5years for fatal and non-fatal MI and stroke. Baseline IL-18 was measured in stored serum samples of incident cases of MI (n=364) or stroke (n=300) and two controls per case. RESULTS: Geometric mean IL-18 levels were higher among the 364 MI cases than the 706 controls; 417.84pg/mL (IQR 316.25, 537.44) compared to 386.90pg/mL (IQR 296.54, 482.33), p(difference)=0.002. IL-18 was positively associated with adverse lipid and inflammatory profiles. Men and women in the top third of baseline IL-18 levels had an age and sex-adjusted odds ratio (OR) for MI of 1.31 (95%CI 0.92, 1.85) compared with those in the lowest third; this attenuated to 1.05 (95%CI 0.72, 1.53) after additional adjustment for established vascular and inflammatory risk factors. Each doubling of IL-18 level was associated with an increased OR for MI 1.34 (95%CI 1.04, 1.72), which was attenuated on adjustment for established vascular and inflammatory risk factors; 1.09 (95%CI 0.83, 1.44). Geometric mean IL-18 levels did not differ between stroke cases and controls. The OR for stroke associated with the highest compared to the lowest tertile of IL-18 was 1.24 (95%CI 0.84, 1.84). Results for MI and stroke did not differ by presence of pre-existing CVD, gender or age. CONCLUSIONS: Circulating IL-18 levels were strongly associated with a range of established and novel risk factors but were not independently associated with risk of MI or stroke in our study.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 23207179
Web of Science ID: 314742800028
URI: http://researchonline.lshtm.ac.uk/id/eprint/505520

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