Extensively drug-resistant tuberculosis in the UK: 1995 to 2007.


Abubakar, I; Moore, J; Drobniewski, F; Kruijshaar, M; Brown, T; Yates, M; Anderson, C; Smith, EG; Magee, J; Lipman, M; McMenamin, J; Ruddy, M; Watson, JM; (2009) Extensively drug-resistant tuberculosis in the UK: 1995 to 2007. Thorax, 64 (6). pp. 512-5. ISSN 0040-6376 DOI: https://doi.org/10.1136/thx.2008.108712

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Abstract

The emergence of multidrug-resistant tuberculosis (MDRTB) and extensively drug-resistant tuberculosis (XDRTB) is a threat to global tuberculosis control. Limited information is, however, available on the outcome of XDRTB cases. This study describes the susceptibility to second- and third-line antituberculosis drugs among MDRTB cases and treatment outcome of identified XDRTB cases. Method: The results of second-line antituberculosis drug susceptibility tests in the UK between January 1995 and December 2007 were retrospectively reviewed and clinicians contacted for treatment outcome of XDRTB cases. Participants included all 678 patients with culture-confirmed MDRTB in the UK. The main outcome measures were the proportion of isolates resistant to second-line antituberculosis drugs and treatment outcome for XDRTB cases.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: TB Centre
PubMed ID: 19318348
Web of Science ID: 266433700012
URI: http://researchonline.lshtm.ac.uk/id/eprint/481

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