Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants


Cairns, M; Gosling, R; Gesase, S; Mosha, J; Greenwood, B; Chandramohan, D; (2009) Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants. Transactions of the Royal Society of Tropical Medicine and Hygiene, 103 (12). pp. 1199-201. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2009.06.007

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Abstract

: Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective drug for IPTi. Work recently conducted in Tanzania, combined with the findings of previous studies, indicates that IPTi is essentially intermittent chemoprophylaxis; consequently, long-acting antimalarials that provide a long period of post-treatment prophylaxis will be the most effective alternative to SP. However, because of concerns about development of drug resistance, new combinations of long-acting drugs are urgently needed.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Malaria Centre
Centre for Maternal, Reproductive and Child Health (MARCH)
Antimicrobial Resistance Centre (AMR)
Tropical Epidemiology Group
PubMed ID: 19740503
Web of Science ID: 272648500005
URI: http://researchonline.lshtm.ac.uk/id/eprint/4763

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