Antoun, Elie; Issarapu, Prachand; di Gravio, Chiara; Shrestha, Smeeta; Betts, Modupeh; Saffari, Ayden; Sahariah, Sirazul A; Sankareswaran, Alagu; Arumalla, Manisha; Prentice, Andrew M; +5 more... Fall, Caroline HD; Silver, Matt J; Chandak, Giriraj R; Lillycrop, Karen A; EMPHASIS study group; EMPHASIS study group; (2022) DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study. Clinical epigenetics, 14 (1). 6-. ISSN 1868-7075 DOI: https://doi.org/10.1186/s13148-021-01213-3
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Abstract
BACKGROUND: The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have investigated epigenetic associations with CMD risk factors in children from low- and middle-income countries. We sought to identify associations between DNA methylation (DNAm) and CMD risk factors in children from India and The Gambia. RESULTS: Using the Illumina Infinium HumanMethylation 850 K Beadchip array, we interrogated DNAm in 293 Gambian (7-9 years) and 698 Indian (5-7 years) children. We identified differentially methylated CpGs (dmCpGs) associated with systolic blood pressure, fasting insulin, triglycerides and LDL-Cholesterol in the Gambian children; and with insulin sensitivity, insulinogenic index and HDL-Cholesterol in the Indian children. There was no overlap of the dmCpGs between the cohorts. Meta-analysis identified dmCpGs associated with insulin secretion and pulse pressure that were different from cohort-specific dmCpGs. Several differentially methylated regions were associated with diastolic blood pressure, insulin sensitivity and fasting glucose, but these did not overlap with the dmCpGs. We identified significant cis-methQTLs at three LDL-Cholesterol-associated dmCpGs in Gambians; however, methylation did not mediate genotype effects on the CMD outcomes. CONCLUSION: This study identified cardiometabolic biomarkers associated with differential DNAm in Indian and Gambian children. Most associations were cohort specific, potentially reflecting environmental and ethnic differences.
Item Type | Article |
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Faculty and Department | MRC Gambia > GM-Nutrition Theme |
Research Centre | Centre for Maternal, Reproductive and Child Health (MARCH) |
PubMed ID | 35000590 |
Elements ID | 169704 |
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Licence: Creative Commons: Attribution 4.0
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