Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial.
Porco, Travis C;
Hart, John;
Arzika, Ahmed M;
Weaver, Jerusha;
Kalua, Khumbo;
Mrango, Zakayo;
Cotter, Sun Y;
Stoller, Nicole E;
O'Brien, Kieran S;
Fry, Dionna M;
+7 more...Vanderschelden, Benjamin;
Oldenburg, Catherine E;
West, Sheila K;
Bailey, Robin L;
Keenan, Jeremy D;
Lietman, Thomas M;
Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Rési;
(2019)
Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68 (12).
pp. 2114-2116.
ISSN 1058-4838
DOI: https://doi.org/10.1093/cid/ciy973
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In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.