Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

Wong, JLC; Mason, AJ; Gordon, AC; Brett, SJ; (2018) Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size? BMJ open, 8 (8). e020068. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2017-020068

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