Plasmodium-associated changes in human odor attract mosquitoes.


Robinson, A; Busula, AO; Voets, MA; Beshir, KB; Caulfield, JC; Powers, SJ; Verhulst, NO; Winskill, P; Muwanguzi, J; Birkett, MA; Smallegange, RC; Masiga, DK; Mukabana, WR; Sauerwein, RW; Sutherland, CJ; Bousema, T; Pickett, JA; Takken, W; Logan, JG; de Boer, JG; (2018) Plasmodium-associated changes in human odor attract mosquitoes. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.1721610115

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Abstract

Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector–host contacts and increased transmission. Indeed, naturally Plasmodium-infected children have been shown to attract more mosquitoes than parasite-free children. Here, we demonstrate Plasmodium-induced increases in the attractiveness of skin odor in Kenyan children and reveal quantitative differences in the production of specific odor components in infected vs. parasite-free individuals. We found the aldehydes heptanal, octanal, and nonanal to be produced in greater amounts by infected individuals and detected by mosquito antennae. In behavioral experiments, we demonstrated that these, and other, Plasmodium-induced aldehydes enhanced the attractiveness of a synthetic odor blend mimicking “healthy” human odor. Heptanal alone increased the attractiveness of “parasite-free” natural human odor. Should the increased production of these aldehydes by Plasmodium-infected humans lead to increased mosquito biting in a natural setting, this would likely affect the transmission of malaria.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
PubMed ID: 29666273
URI: http://researchonline.lshtm.ac.uk/id/eprint/4647410

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