Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study.


Kamara, DA; Ryom, L; Ross, M; Kirk, O; Reiss, P; Morlat, P; Moranne, O; Fux, CA; Mocroft, A; Sabin, C; Lundgren, JD; Smith, CJ; D:A:D study Group, ; , COLLABORATORS; Powderly, B; Shortman, N; Moecklinghoff, C; Reilly, G; Franquet, X; Ryom, L; Sabin, CA; Kamara, D; Smith, C; Phillips, A; Mocroft, A; Tverland, J; Mansfeld, M; Nielsen, J; Raben, D; Lundgren, JD; Brandt, R; Rickenbach, M; Fanti, I; Krum, E; Hillebregt, M; Geffard, S; Sundström, A; Delforge, M; Fontas, E; Torres, F; McManus, H; Wright, S; Kjær, J; Sjøl, A; Meidahl, P; Helweg-Larsen, J; Iversen, J; Ryom, L; Mocroft, A; Kirk, O; Reiss, P; Ross, M; Fux, CA; Morlat, P; Moranne, O; Kesselring, AM; Kamara, DA; Smith, C; Lundgren, JD; Smith, C; Ryom, L; Phillips, A; Weber, R; Morlat, P; Pradier, C; Reiss, P; Friis-Møller, N; Kowalska, J; Lundgren, JD; Sabin, C; Law, M; d'Arminio Monforte, A; Dabis, F; Bruyand, M; Reiss, P; Smith, C; Kamara, DA; Bower, M; Fätkenheuer, G; Donald, A; Grulich, A; Ryom, L; Lundgren, JD; Reiss, P; Zaheri, S; Hillebregt, M; Gras, L; Prins, JM; Kuijpers, TW; Scherpbier, HJ; van der Meer, JT; Wit, FW; Godfried, MH; Reiss, P; van der Poll, d; Nellen, FJ; Lange, JM; Geerlings, SE; van Vugt, M; Pajkrt, D; Bos, D; van der Valk, D; Grijsen, ML; Wiersinga, WJ; Goorhuis, A; Hovius, JW; Lowe, S; Lashof, A; Posthouwer, D; Ammerlaan, HS; Pronk, MJ; van der Ende, ME; de Vries-Sluijs, TE; Schurink, CA; Nouwen, JL; Verbon, A; Rijnders, BJ; van Gorp, EC; van der Feltz, M; Driessen, GJ; van Rossum, AM; Branger, J; Schippers, F; van Nieuwkoop, C; van Elzakker, EP; Groeneveld, PH; Bouwhuis, JW; Soetekouw, R; ten Kate, RW; Kroon, FP; van Dissel, JT; Arend, SM; de Boer, MG; Jolink, H; ter Vollaard, HJ; Bauer, MP; den Hollander, JG; Pogany, K; van Twillert, D; Kortmann, W; Stuart, JW; Diederen, BM; Leyten, MS; Gelinck, LB; Kootstra, GJ; Delsing, CE; Brinkman, K; Blok, WL; Frissen, PH; Schouten, WE; van den Berk, GE; van Kasteren, ME; Brouwer, AE; Veenstra, J; Lettinga, KD; Mulder, JW; Vrouenraets, SM; Lauw, FN; van Eeden, A; Verhagen, DW; Sprenger, HG; Doedens, R; Scholvinck, EH; van Assen, S; Bierman, WF; Koopmans, PP; Keuter, M; van der Ven, AJ; ter Hofstede, HJ; Dofferhoff, AS; Warris, A; van Crevel, R; Hoepelman, AI; Mudrikova, T; Schneider, MM; Ellerbroek, PM; Oosterheert, JJ; Arends, JE; Wassenberg, MW; Barth, RE; van Agtmael, M; Perenboom, RM; Claessen, FA; Bomers, M; Peters, EJ; Geelen, SP; Wolfs, TF; Bont, LJ; Richter, C; van der Berg, JP; Gisolf, EH; van den Berge, M; Stegeman, A; van Vonderen, MG; van Houte, DP; Weijer, S; el Moussaoui, R; Winkel, C; Muskiet, F; Durand, ; Voigt, R; Dabis, F; Bruyand, M; Chêne, G; Dabis, F; Lawson-Ayayi, S; Thiébaut, R; Bonnal, F; Bonnet, F; Bernard, N; Caunègre, L; Cazanave, C; Ceccaldi, J; Chambon, D; Chossat, I; Dauchy, FA; De Witte, S; Dupon, M; Duffau, P; Dutronc, H; Farbos, S; Gaborieau, V; Gemain, MC; Gerard, Y; Greib, C; Hessamfar, M; Lacoste, D; Lataste, P; Lafarie, S; Lazaro, E; Malvy, D; Meraud, JP; Mercié, P; Monlun, E; Morlat, P; Neau, D; Ochoa, A; Pellegrin, JL; Pistone, T; Ragnaud, JM; Receveur, MC; Tchamgoué, S; Vandenhende, MA; Viallard, JF; Moreau, JF; Pellegrin, I; Fleury, H; Lafon, ME; Masquelier, B; Trimoulet, P; Breilh, D; Haramburu, F; Miremont-Salamé, G; Blaizeau, MJ; Decoin, M; Delaune, J; Delveaux, S; D'Ivernois, C; Hanapier, C; Leleux, O; Uwamaliya-Nziyumvira, B; Sicard, X; Geffard, S; Palmer, G; Touchard, D; Bonnet, F; Dupon, M; Mercié, P; Morlat, P; Pellegrin, JL; Ragnaud, JM; Dabis, F; Law, M; Petoumenos, K; McManus, H; Wright, S; Bendall, C; Moore, R; Edwards, S; Hoy, J; Watson, K; Roth, N; Nicholson, J; Bloch, M; Franic, T; Baker, D; Vale, R; Carr, A; Cooper, D; Chuah, J; Ngieng, M; Nolan, D; Skett, J; Calvo, G; Torres, F; Mateu, S; Domingo, P; Sambeat, MA; Gatell, J; Del Cacho, E; Cadafalch, J; Fuster, M; Codina, C; Sirera, G; Vaqué, A; De Wit, S; Clumeck, N; Delforge, M; Necsoi, C; Clumeck, N; Gennotte, AF; Gerard, M; Kabeya, K; Konopnicki, D; Libois, A; Martin, C; Payen, MC; Semaille, P; Van Laethem, Y; Neaton, J; Bartsch, G; El-Sadr, WM; Krum, E; Thompson, G; Wentworth, D; Luskin-Hawk, R; Telzak, E; El-Sadr, WM; Abrams, DI; Cohn, D; Markowitz, N; Arduino, R; Mushatt, D; Friedland, G; Perez, G; Tedaldi, E; Fisher, E; Gordin, F; Crane, LR; Sampson, J; Baxter, J; Lundgren, J; Kirk, O; Mocroft, A; Cozzi-Lepri, A; Grint, D; Podlekareva, D; Kjær, J; Peters, L; Reekie, J; Kowalska, J; Tverland, J; Fischer, AH; Nielsen, J; Losso, M; Elias, C; Vetter, N; Zangerle, R; Karpov, I; Vassilenko, A; Mitsura, VM; Suetnov, O; Clumeck, N; Delforge, M; Colebunders, R; Vandekerckhove, L; Hadziosmanovic, V; Kostov, K; Machala, L; Begovac, J; Jilich, D; Sedlacek, D; Nielsen, J; Kronborg, G; Gerstoft, J; Benfield, T; Larsen, M; Katzenstein, T; Hansen, AB; Skinhøj, P; Pedersen, C; Ostergaard, L; Zilmer, K; Smidt, J; Ristola, M; Katlama, C; Viard, J; Girard, P; Livrozet, JM; Vanhems, P; Pradier, C; Dabis, F; Neau, D; Rockstroh, J; Schmidt, R; van Lunzen, J; Degen, O; Stellbrink, HJ; Staszewski, S; Bickel, M; Fätkenheuer, G; Kosmidis, J; Gargalianos, P; Xylomenos, G; Perdios, J; Panos, G; Filandras, A; Karabatsaki, E; Sambatakou, H; Banhegyi, D; Mulcahy, F; Yust, I; Turner, D; Burke, M; Pollack, S; Hassoun, G; Maayan, S; Vella, S; Esposito, R; Mazeu, I; Mussini, C; Arici, C; Pristera, R; Mazzotta, F; Gabbuti, A; Vullo, V; Lichtner, M; Chirianni, A; Montesarchio, E; Gargiulo, M; Antonucci, G; Testa, A; Narciso, P; Vlassi, C; Zaccarelli, M; Lazzarin, A; Castagna, A; Gianotti, N; Galli, M; Ridolfo, A; Rozentale, B; Zeltina, I; Chaplinskas, S; Hemmer, R; Staub, T; Reiss, P; Ormaasen, V; Maeland, A; Bruun, J; Knysz, B; Gasiorowski, J; Horban, A; Bakowska, E; Grzeszczuk, A; Flisiak, R; Boron-Kaczmarska, A; Pynka, M; Parczewski, M; Beniowski, M; Mularska, E; Trocha, H; Jablonowska, E; Malolepsza, E; Wojcik, K; Antunes, F; Doroana, M; Caldeira, L; Mansinho, K; Maltez, F; Duiculescu, D; Rakhmanova, A; Babes, V; Zakharova, N; Jevtovic, D; Mokráš, M; Staneková, D; Tomazic, J; González-Lahoz, J; Soriano, V; Labarga, P; Medrano, J; Moreno, S; Rodriguez, JM; Clotet, B; Jou, A; Paredes, R; Tural, C; Puig, J; Bravo, I; Gatell, JM; Miró, JM; Domingo, P; Gutierrez, M; Karlsson, A; Mateo, G; Sambeat, MA; Flamholc, L; Ledergerber, B; Weber, R; Francioli, P; Cavassini, M; Hirschel, B; Boffi, E; Kravchenko, E; Furrer, H; Battegay, M; Elzi, L; Chentsova, N; Frolov, V; Kutsyna, G; Servitskiy, S; Krasnov, M; Barton, S; Johnson, AM; Mercey, D; Phillips, A; Johnson, MA; Mocroft, A; Murphy, M; Weber, J; Scullard, G; Fisher, M; Leen, C; Morfeldt, L; Thulin, G; Sundström, A; Åkerlund, B; Koppel, K; Flamholc, L; Håkangård, C; Moroni, M; Angarano, G; Antinori, A; Armignacco, O; Castelli, F; Cauda, R; Di Perri, G; Galli, M; Iardino, R; Ippolito, G; Lazzarin, A; Perno, CF; von Schloesser, F; Viale, P; Antinori, A; Castagna, A; Ceccherini-Silberstein, F; Cozzi-Lepri, A; Girardi, E; Lo Caputo, S; Mussini, C; Puoti, M; Andreoni, M; Ammassari, A; Antinori, A; Balotta, C; Bonfanti, P; Bonora, S; Borderi, M; Capobianchi, MR; Castagna, A; Ceccherini-Silberstein, F; Cingolani, A; Cinque, P; Cozzi-Lepri, A; De Luca, A; Di Biagio, A; Girardi, E; Gianotti, N; Gori, A; Guaraldi, G; Lapadula, G; Lichtner, M; Madeddu, G; Maggiolo, F; Marchetti, G; Marcotullio, S; Monno, L; Mussini, C; Puoti, M; Quiros, E; Rusconi, S; Cozzi-Lepri, A; Cicconi, P; Fanti, I; Formenti, T; Galli, L; Lorenzini, P; Giacometti, A; Costantini, A; Angarano, G; Monno, L; Santoro, C; Maggiolo, F; Suardi, C; Viale, P; Vanino, E; Verucchi, G; Castelli, F; Quiros Roldan, E; Minardi, C; Quirino, T; Abeli, C; Manconi, PE; Piano, P; Vecchiet, J; Falasca, K; Sighinolfi, L; Segala, D; Mazzotta, F; Cassola, G; Viscoli, G; Alessandrini, A; Piscopo, R; Mazzarello, G; Mastroianni, C; Belvisi, V; Bonfanti, P; Caramma, I; Castelli, AP; Galli, M; Lazzarin, A; Rizzardini, G; Puoti, M; Ridolfo, AL; Piolini, R; Castagna, A; Salpietro, S; Carenzi, L; Moioli, MC; Cicconi, P; Marchetti, G; Mussini, C; Puzzolante, C; Gori, A; Onofrio, M; Lapadula, G; Abrescia, N; Chirianni, A; Guida, MG; Baldelli, F; Francisci, D; Parruti, G; Ursini, T; Magnani, G; Ursitti, MA; Cauda, R; Andreoni, M; Antinori, A; Vullo, V; Cingolani, A; d' Avino, A; Ammassari, A; Gallo, L; Nicastri, E; Acinapura, R; Capozzi, M; Libertone, R; Tebano, G; Cattelan, A; Mura, MS; Madeddu, G; Caramello, P; Di Perri, G; Orofino, GC; Bonora, S; Sciandra, M; Pellizzer, G; Manfrin, V; Pradier, C; Fontas, E; Caissotti, C; Dellamonica, P; Bernard, E; Cua, E; De Salvador- Guillouet, F; Durant, J; Ferrando, S; Mondain-Miton, V; Naqvi, A; Perbost, I; Prouvost-Keller, B; Pillet, S; Pugliese, P; Rahelinirina, V; Roger, PM; Dollet, K; Aubert, V; Barth, J; Battegay, M; Bernasconi, E; Böni, J; Bucher, HC; Burton- Jeangros, C; Calmy, A; Cavassini, M; Egger, M; Elzi, L; Fehr, J; Fellay, J; Furrer, H; Fux, CA; Gorgievski, M; Günthard, H; Haerry, D; Hasse, B; Hirsch, HH; Hösli, I; Kahlert, C; Kaiser, L; Keiser, O; Klimkait, T; Kovari, H; Ledergerber, B; Martinetti, G; de Tejada, BM; Metzner, K; Müller, N; Nadal, D; Pantaleo, G; Rauch, A; Regenass, A; Rickenbach, M; Rudin, C; Schmid, P; Schultze, D; Schöni-Affolter, F; Schüpbach, J; Speck, R; Taffé, P; Tarr, P; Telenti, A; Trkola, A; Vernazza, P; Weber, R; Yerly, S; (2014) Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study. BMC nephrology, 15. p. 51. ISSN 1471-2369 DOI: https://doi.org/10.1186/1471-2369-15-51

[img]
Preview
Text - Published Version
License:

Download (457kB) | Preview

Abstract

No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glomerular filtration rate (eGFR) >90 ml/min/1.73 m2 (using Cockcroft Gault) in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study from 2004 to 2011. Two definitions were evaluated; RP definition A: An average eGFR decline (slope) ≥5 ml/min/1.73 m2/year over four years of follow-up with ≥3 eGFR measurements/year, last eGFR <90 ml/min/1.73 m2 and an absolute decline ≥5 ml/min/1.73 m2/year in two consecutive years. RP definition B: An absolute annual decline ≥5 ml/min/1.73 m2/year in each year and last eGFR <90 ml/min/1.73 m2. Sensitivity analyses were performed considering two and three years' follow-up. The percentage with and without RP who went on to subsequently develop incident chronic kidney disease (CKD; 2 consecutive eGFRs <60 ml/min/1.73 m2 and 3 months apart) was calculated. 22,603 individuals had baseline eGFR ≥90 ml/min/1.73 m2. 108/3655 (3.0%) individuals with ≥4 years' follow-up and ≥3 measurements/year experienced RP under definition A; similar proportions were observed when considering follow-up periods of three (n=195/6375; 3.1%) and two years (n=355/10756; 3.3%). In contrast under RP definition B, greater proportions experienced RP when considering two years (n=476/10756; 4.4%) instead of three (n=48/6375; 0.8%) or four (n=15/3655; 0.4%) years' follow-up. For RP definition A, 13 (12%) individuals who experienced RP progressed to CKD, and only (21) 0.6% of those without RP progressed to CKD (sensitivity 38.2% and specificity 97.4%); whereas for RP definition B, fewer RP individuals progressed to CKD. Our results suggest using three years' follow-up and at least two eGFR measurements per year is most appropriate for a RP definition, as it allows inclusion of a reasonable number of individuals and is associated with the known risk factors. The definition does not necessarily identify all those that progress to incident CKD, however, it can be used alongside other renal measurements to early identify and assess those at risk of developing CKD. Future analyses will use this definition to identify other risk factors for RP, including the role of antiretrovirals.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Related URLs:
PubMed ID: 24666792
Web of Science ID: 335066800001
URI: http://researchonline.lshtm.ac.uk/id/eprint/4646607

Statistics


Download activity - last 12 months
Downloads since deposit
2Downloads
17Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item