Fermented dairy products modulate Citrobacter rodentium-induced colonic hyperplasia.

Collins, JW; Chervaux, C; Raymond, B; Derrien, M; Brazeilles, R; Kosta, A; Chambaud, I; Crepin, VF; Frankel, G; (2014) Fermented dairy products modulate Citrobacter rodentium-induced colonic hyperplasia. The Journal of infectious diseases, 210 (7). pp. 1029-41. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiu205

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We evaluated the protective effects of fermented dairy products (FDPs) in an infection model, using the mouse pathogen Citrobacter rodentium (CR). Treatment of mice with FDP formulas A, B, and C or a control product did not affect CR colonization, organ specificity, or attaching and effacing lesion formation. Fermented dairy product A (FDP-A), but neither the supernatant from FDP-A nor β-irradiated (IR) FDP-A, caused a significant reduction in colonic crypt hyperplasia and CR-associated pathology. Profiling the gut microbiota revealed that IR-FDP-A promoted higher levels of phylotypes belonging to Alcaligenaceae and a decrease in Lachnospiraceae (Ruminococcus) during CR infection. Conversely, FDP-A prevented a decrease in Ruminococcus and increased Turicibacteraceae (Turicibacter). Importantly, loss of Ruminococcus and Turicibacter has been associated with susceptibility to dextran sodium sulfate-induced colitis. Our results demonstrate that viable bacteria in FDP-A reduced CR-induced colonic crypt hyperplasia and prevented the loss of key bacterial genera that may contribute to disease pathology.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 24706936
URI: http://researchonline.lshtm.ac.uk/id/eprint/4646451


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