Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes.


Dahan, S; Knutton, S; Shaw, RK; Crepin, VF; Dougan, G; Frankel, G; (2004) Transcriptome of enterohemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes. Infection and immunity, 72 (9). pp. 5452-9. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.72.9.5452-5459.2004

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Abstract

Using a DNA microarray, we determined changes in enterohemorrhagic Escherichia coli O157:H7 gene expression during binding to plasma membranes. Analysis of the complete transcriptomes of the bound bacteria revealed increased levels of stress-associated mRNAs and decreased levels of mRNA encoding proteins involved in translation and type III secretion.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 15322044
URI: http://researchonline.lshtm.ac.uk/id/eprint/4646409

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