Subversion of actin dynamics by EPEC and EHEC.


Caron, E; Crepin, VF; Simpson, N; Knutton, S; Garmendia, J; Frankel, G; (2006) Subversion of actin dynamics by EPEC and EHEC. Current opinion in microbiology, 9 (1). pp. 40-5. ISSN 1369-5274 DOI: https://doi.org/10.1016/j.mib.2005.12.008

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Abstract

During the course of infection, enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC, respectively) subvert the host cell signalling machinery and hijack the actin cytoskeleton to tighten their interaction with the gut epithelium, while avoiding phagocytosis by professional phagocytes. Much progress has been made recently in our understanding of how EPEC and EHEC regulate the pathways leading to local activation of two regulators of actin cytoskeleton dynamics, the Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex. A recent highlight is the unravelling of functions for effector proteins (particularly Tir, TccP, Map and EspG/EspG2) that are injected into the host cell by a type III secretion system.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 16406772
URI: http://researchonline.lshtm.ac.uk/id/eprint/4646404

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