Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission.


Guelbéogo, WM; Gonçalves, BP; Grignard, L; Bradley, J; Serme, SS; Hellewell, J; Lanke, K; Zongo, S; Sepúlveda, N; Soulama, I; Wangrawa, DW; Yakob, L; Sagnon, N; Bousema, T; Drakeley, C; (2018) Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission. eLife, 7. ISSN 2050-084X DOI: https://doi.org/10.7554/eLife.32625

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Abstract

Variation in biting frequency by Anopheles mosquitoes can explain some of the heterogeneity in malaria transmission in endemic areas. In this study in Burkina Faso, we assessed natural exposure to mosquitoes by matching the genotype of blood meals from 1066 mosquitoes with blood from residents of local households. We observed that the distribution of mosquito bites exceeded the Pareto rule (20/80) in two of the three surveys performed (20/85, 76, and 96) and, at its most pronounced, is estimated to have profound epidemiological consequences, inflating the basic reproduction number of malaria by 8-fold. The distribution of bites from sporozoite-positive mosquitoes followed a similar pattern, with a small number of individuals within households receiving multiple potentially infectious bites over the period of a few days. Together, our findings indicate that heterogeneity in mosquito exposure contributes considerably to heterogeneity in infection risk and suggest significant variation in malaria transmission potential.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
PubMed ID: 29357976
Web of Science ID: 423039600001
URI: http://researchonline.lshtm.ac.uk/id/eprint/4646196

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