Neurological Sequelae of Adult Meningitis in Africa: A Systematic Literature Review.


Goldberg, DW; Tenforde, MW; Mitchell, HK; Jarvis, JN; (2017) Neurological Sequelae of Adult Meningitis in Africa: A Systematic Literature Review. Open Forum Infect Dis, 5 (1). ofx246. ISSN 2328-8957 DOI: https://doi.org/10.1093/ofid/ofx246

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Abstract

The high human immunodeficiency virus (HIV) prevalence in sub-Saharan Africa has markedly changed the epidemiology and presentation of adult meningitis. We conducted a systematic review using PubMed, Embase, Ovid, CENTRAL, and African Index Medicus to identify studies in Africa with data on neurological outcomes in adults after meningitis. We found 22 articles meeting inclusion criteria. From 4 studies with predominately pneumococcal meningitis, a median of 19% of survivors experienced hearing loss up to 40 days. Two studies of cryptococcal meningitis evaluated 6- to 12-month outcomes; in one, 41% of survivors had global neurocognitive impairment and 20% severe impairment at 1 year, and in a second 30% of survivors had intermediate disability and 10% severe disability at 6 months. A single small study of patients with tuberculosis/HIV found marked disability in 20% (6 of 30) at 9 months. Despite the high burden of meningitis in sub-Saharan Africa, little is known about neurological outcomes of patients with HIV-associated meningitides.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 29322063
URI: http://researchonline.lshtm.ac.uk/id/eprint/4646091

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