The yeast prion protein Ure2: insights into the mechanism of amyloid formation.


Chen, LJ; Sawyer, EB; Perrett, S; (2011) The yeast prion protein Ure2: insights into the mechanism of amyloid formation. Biochemical Society transactions, 39 (5). pp. 1359-64. ISSN 0300-5127 DOI: https://doi.org/10.1042/BST0391359

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Abstract

Ure2, a regulator of nitrogen metabolism, is the protein determinant of the [URE3] prion state in Saccharomyces cerevisiae. Upon conversion into the prion form, Ure2 undergoes a heritable conformational change to an amyloid-like aggregated state and loses its regulatory function. A number of molecular chaperones have been found to affect the prion properties of Ure2. The studies carried out in our laboratory have been aimed at elucidating the structure of Ure2 fibrils, the mechanism of amyloid formation and the effect of chaperones on the fibril formation of Ure2.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 21936815
URI: http://researchonline.lshtm.ac.uk/id/eprint/4645912

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