Genomic history of the seventh pandemic of cholera in Africa.


Weill, FX; Domman, D; Njamkepo, E; Tarr, C; Rauzier, J; Fawal, N; Keddy, KH; Salje, H; Moore, S; Mukhopadhyay, AK; Bercion, R; Luquero, FJ; Ngandjio, A; Dosso, M; Monakhova, E; Garin, B; Bouchier, C; Pazzani, C; Mutreja, A; Grunow, R; Sidikou, F; Bonte, L; Breurec, S; Damian, M; Njanpop-Lafourcade, BM; Sapriel, G; Page, AL; Hamze, M; Henkens, M; Chowdhury, G; Mengel, M; Koeck, JL; Fournier, JM; Dougan, G; Grimont, PAD; Parkhill, J; Holt, KE; Piarroux, R; Ramamurthy, T; Quilici, ML; Thomson, NR; (2017) Genomic history of the seventh pandemic of cholera in Africa. Science (New York, NY), 358 (6364). pp. 785-789. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.aad5901

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Abstract

The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 29123067
Web of Science ID: 414847100044
URI: http://researchonline.lshtm.ac.uk/id/eprint/4645828

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