Neonatal Encephalopathy With Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis.

Tann, CJ; Martinello, KA; Sadoo, S; Lawn, JE; Seale, AC; Vega-Poblete, M; Russell, NJ; Baker, CJ; Bartlett, L; Cutland, C; Gravett, MG; Ip, M; Le Doare, K; Madhi, SA; Rubens, CE; Saha, SK; Schrag, S; Sobanjo-Ter Meulen, A; Vekemans, J; Heath, PT; GBS Neonatal Encephalopathy Investigator Group, ; , COLLABORATORS; Garcia-Alix, A; Boo, NY; Martinez-Biarge, M; Cheong, J; Cowan, F; de Vries, LS; Arca-Diaz, G; Edwards, AD; Ellis, M; Gale, C; Glass, HC; Groenendaal, F; Gunn, A; Hayes, B; Jacobs, SE; Johnson, CT; Kali, G; Manne, M; Massaro, AN; Robertson, NJ; Shah, P; Shankaran, S; Tann, CJ; Thayyil, S; Thoresen, M; Walsh, BH; Wintermark, P; Lee, ACC; (2017) Neonatal Encephalopathy With Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis. Clinical infectious diseases, 65 (suppl_2). S173-S189. ISSN 1058-4838 DOI:

Text - Published Version

Download (6MB) | Preview


Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairment. Infection can sensitize the newborn brain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed. This paper is the ninth in an 11-article series estimating the burden of GBS disease; here we aim to assess the proportion of GBS in NE cases. We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups reporting GBS-associated NE. Meta-analyses estimated the proportion of GBS disease in NE and mortality risk. UK population-level data estimated the incidence of GBS-associated NE. Four published and 25 unpublished datasets were identified from 13 countries (N = 10436). The proportion of NE associated with GBS was 0.58% (95% confidence interval [CI], 0.18%-.98%). Mortality was significantly increased in GBS-associated NE vs NE alone (risk ratio, 2.07 [95% CI, 1.47-2.91]). This equates to a UK incidence of GBS-associated NE of 0.019 per 1000 live births. The consistent increased proportion of GBS disease in NE and significant increased risk of mortality provides evidence that GBS infection contributes to NE. Increased information regarding this and other organisms is important to inform interventions, especially in low- and middle-resource contexts.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Related URLs:
PubMed ID: 29117330
Web of Science ID: 414511400009


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item