Advancing prevention of sexually transmitted infections through point-of-care testing: target product profiles and landscape analysis.


Toskin, I; Murtagh, M; Peeling, RW; Blondeel, K; Cordero, J; Kiarie, J; (2017) Advancing prevention of sexually transmitted infections through point-of-care testing: target product profiles and landscape analysis. Sexually transmitted infections, 93 (S4). S69-S80. ISSN 1368-4973 DOI: https://doi.org/10.1136/sextrans-2016-053071

[img]
Preview
Text - Published Version
License:

Download (384kB) | Preview

Abstract

Advancing the field of point-of-care testing (POCT) for STIs can rapidly and substantially improve STI control and prevention by providing targeted, essential STI services (case detection and screening). POCT enables definitive diagnosis and appropriate treatment in a single visit and home and community-based testing. Since 2014, the WHO Department of Reproductive Health and Research, in collaboration with technical partners, has completed four landscape analyses of promising diagnostics for use at or near the point of patient care to detect syphilis, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and the human papillomavirus. The analyses comprised a literature review and interviews. Two International Technical Consultations on STI POCTs (2014 and 2015) resulted in the development of target product profiles (TPP). Experts in STI microbiology, laboratory diagnostics, clinical management, public health and epidemiology participated in the consultations with representation from all WHO regions. The landscape analysis identified diagnostic tests that are either available on the market, to be released in the near future or in the pipeline. The TPPs specify 28 analytical and operational characteristics of POCTs for use in different populations for surveillance, screening and case management. None of the tests that were identified in the landscape analysis met all of the targets of the TPPs. More efforts of the global health community are needed to accelerate access to affordable quality-assured STI POCTs, particularly in low- and middle-income countries, by supporting the development of new diagnostic platforms as well as strengthening the validation and implementation of existing diagnostics according to internationally endorsed standards and the best available evidence.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 29223965
URI: http://researchonline.lshtm.ac.uk/id/eprint/4645581

Statistics


Download activity - last 12 months
Downloads since deposit
21Downloads
23Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item