Variability in intra-household transmission of Ebola virus, and estimation of the household secondary attack rate.


Glynn, JR; Bower, H; Johnson, S; Turay, C; Sesay, D; Mansaray, SH; Kamara, O; Kamara, AJ; Bangura, MS; Checchi, F; (2017) Variability in intra-household transmission of Ebola virus, and estimation of the household secondary attack rate. The Journal of infectious diseases, 217 (2). pp. 232-237. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jix579

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Abstract

: Transmission between family members accounts for most Ebola virus transmission, but little is known about determinants of intrahousehold spread. From detailed exposure histories, intrahousehold transmission chains were created for 94 households of Ebola survivors in Sierra Leone: 109 (co-)primary cases gave rise to 317 subsequent cases (0-100% of those exposed). Larger households were more likely to have subsequent cases, and the proportion of household members affected depended on individual and household-level factors. More transmissions occurred from older than from younger cases, and from those with more severe disease. The estimated household secondary attack rate was 18%.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 29140442
Web of Science ID: 419613300010
URI: http://researchonline.lshtm.ac.uk/id/eprint/4645459

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