Activation of natural killer cells during microbial infections.


Horowitz, A; Stegmann, KA; Riley, EM; (2011) Activation of natural killer cells during microbial infections. Front Immunol, 2. p. 88. ISSN 1664-3224 DOI: https://doi.org/10.3389/fimmu.2011.00088

[img]
Preview
Text - Published Version
License:

Download (1MB) | Preview

Abstract

Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines. The ability of NK cells to be very rapidly activated by inflammatory cytokines, to secrete effector cytokines, and to kill infected or stressed host cells, suggests that they may be among the very early responders during infection. Recent studies have also identified a small number of pathogen-derived ligands that can bind to NK cell surface receptors and directly induce their activation. Here we review recent studies that have begun to elucidate the various pathways by which viral, bacterial, and parasite pathogens activate NK cells. We also consider two emerging themes of NK cell-pathogen interactions, namely their contribution to adaptive immune responses and their potential to take on regulatory and immunomodulatory functions.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 22566877
Web of Science ID: 209501200004
URI: http://researchonline.lshtm.ac.uk/id/eprint/457527

Statistics


Download activity - last 12 months
Downloads since deposit
264Downloads
319Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item