Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults.

Demnitz, N; Zsoldos, E; Mahmood, A; Mackay, CE; Kivimäki, M; Singh-Manoux, A; Dawes, H; Johansen-Berg, H; Ebmeier, KP; Sexton, CE; (2017) Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults. Frontiers in aging neuroscience, 9. p. 155. ISSN 1663-4365 DOI:

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Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy, axial diffusivity (AD), and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus, and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
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PubMed ID: 28588477


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