The cost-effectiveness of rotavirus vaccination: Comparative analyses for five European countries and transferability in Europe


Jit, M; Bilcke, J; Mangen, MJJ; Salo, H; Melliez, H; Edmunds, WJ; Yazdan, Y; Beutels, P; (2009) The cost-effectiveness of rotavirus vaccination: Comparative analyses for five European countries and transferability in Europe. Vaccine, 27 (44). pp. 6121-6128. ISSN 0264-410X DOI: 10.1016/j.vaccine.2009.08.030

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Abstract

Cost-effectiveness analyses are usually not directly comparable between countries because of differences in analytical and modelling assumptions. We investigated the cost-effectiveness of rotavirus vaccination in five European Union countries (Belgium, England and Wales, Finland, France and the Netherlands) using a single model, burden of disease estimates supplied by national public health agencies and a subset of common assumptions. Under base case assumptions (vaccination with Rotarix (R), 3% discount rate, health care provider perspective, no herd immunity and quality of life of one caregiver affected by a rotavirus episode) and a cost-effectiveness threshold of (sic)30,000, vaccination is likely to be cost effective in Finland only. However, single changes to assumptions may make it cost effective in Belgium and the Netherlands. The estimated threshold price per dose for Rotarix (R) (excluding administration costs) to be cost effective was (sic)41 in Belgium, (sic)28 in England and Wales, 4651 in Finland, (sic)36 in France and (sic)46 in the Netherlands. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Rotavirus, Vaccination, Cost-effectiveness, EFFICACY, SAFETY, GASTROENTERITIS, AUSTRALIA, VACCINES, INFANTS, DISEASE, BURDEN, CHOICE
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 19715781
Web of Science ID: 271486100005
URI: http://researchonline.lshtm.ac.uk/id/eprint/4508

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