The scope for pneumococcal vaccines that do not prevent transmission.


Flasche, S; (2017) The scope for pneumococcal vaccines that do not prevent transmission. Vaccine, 35 (45). pp. 6043-6046. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2017.09.073

This is the latest version of this item. Earlier version may have full text manuscript

[img] Text - Accepted Version
Restricted to Repository staff only until 3 October 2018.
License:

Download (343kB) | Request a copy

Abstract

: The pneumococcal vaccine pipeline holds candidates developed with the aim to prevent the majority if not all pneumococcal disease. Herd protection is a critical component of the overall impact of current pneumococcal conjugate vaccines (PCVs) and is a prerequisite for disease elimination through an infant vaccination programme. We assessed the scope of a hypothetical pneumococcal vaccine candidate (HPVC) with high clinical efficacy against all pneumococci but that fails to induce such indirect protection. We found that, despite a lack of impact on unvaccinated individuals, HPVC use in infancy may offer similar or superior impact among young children if compared to current PCVs. Hence, it could provide a more affordable alternative to PCVs in particular in settings where most pneumococcal disease is concentrated in children.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 28982625
Web of Science ID: 413883400002
URI: http://researchonline.lshtm.ac.uk/id/eprint/4503960

Available Versions of this Item

Statistics


Download activity - last 12 months
Downloads since deposit
2Downloads
131Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item