Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring.


Lumia, M; Luukkainen, P; Tapanainen, H; Kaila, M; Erkkola, M; Uusitalo, L; Niinistö, S; Kenward, MG; Ilonen, J; Simell, O; Knip, M; Veijola, R; Virtanen, SM; (2011) Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. Pediatric allergy and immunology, 22 (8). pp. 827-35. ISSN 0905-6157 DOI: https://doi.org/10.1111/j.1399-3038.2011.01202.x

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Abstract

BACKGROUND: Fatty acids (FA) modulate the immune system, and it has been proposed that they affect the incidence of IgE-mediated allergic diseases. We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring.<br/> METHODS: We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. Maternal dietary intake during pregnancy (8th month) was assessed by a validated 181-item food frequency questionnaire. The occurrence of asthma was assessed at the age of 5 yr with a questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC). Cox proportional hazards regression was used for the statistical analyses.<br/> RESULTS: Low maternal intakes of ?-linolenic acid (18:3n-3) [lowest quarter vs. mid-half HR 1.67 (95% CI 1.12-2.48)] and total n-3-polyunsaturated fatty acids (PUFA) [HR 1.66 (95% CI 1.11-2.48)] during pregnancy were associated with an increased risk of asthma in the offspring, while a low intake of arachidonic acid (20:4n-6) [HR 0.52 (95% CI 0.32-0.84)] and high intake of total saturated fatty acids [highest quarter vs. mid-half HR 0.55 (95% CI 0.34-0.90)] and palmitic acid (16:0) [HR 0.51 (95% CI 0.31-0.83)] were associated with a decreased risk of asthma. The ratios of n-6 to n-3-PUFA and 18:2n-6 to 18:3n-3, and the maternal intake of oils, fish and fish products, showed no association with the risk of asthma. The associations found were independent of several perinatal and clinical confounders.<br/> CONCLUSION: Maternal intake of FA during pregnancy was associated with childhood asthma. Maternal ?-linolenic acid, total n-3 PUFA and palmitic acid intake may decrease, while arachidonic acid intake may increase the risk of asthma in the offspring.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 21929596
Web of Science ID: 298095300011
URI: http://researchonline.lshtm.ac.uk/id/eprint/45

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