Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan.


Raza, SA; Franceschi, S; Pallardy, S; Malik, FR; Avan, BI; Zafar, A; Ali, SH; Pervez, S; Serajuddaula, S; Snijders, PJ; van Kemenade, FJ; Meijer, CJ; Shershah, S; Clifford, GM; (2010) Human papillomavirus infection in women with and without cervical cancer in Karachi, Pakistan. British journal of cancer, 102 (11). pp. 1657-60. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6605664

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Abstract

BACKGROUND No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in predominantly Muslim countries in Asia. METHODS Cervical specimens were obtained from 899 married women aged 15-59 years from the general population of Karachi, Pakistan and from 91 locally diagnosed invasive cervical cancers (ICCs). HPV was detected using a GP5+/6+ PCR-based assay. RESULTS The prevalence of HPV in the general population was 2.8%, with no evidence of higher HPV prevalence in young women. The positivity of HPV was associated with women's lifetime number of sexual partners, but particularly with the age difference between spouses and other husbands' characteristics, such as extramarital sexual relationships and regular absence from home. The HPV16/18 accounted for 24 and 88% of HPV-positive women in the general population and ICC, respectively. CONCLUSION Cervical cancer prevention policies should take into account the low HPV prevalence and low acceptability of gynaecological examination in this population.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Maternal and Child Health Intervention Research Group
PubMed ID: 20407442
Web of Science ID: 278133200012
URI: http://researchonline.lshtm.ac.uk/id/eprint/448554

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