Assessing publication bias in genetic association studies: evidence from a recent meta-analysis.


Munafò, MR; Clark, TG; Flint, J; (2004) Assessing publication bias in genetic association studies: evidence from a recent meta-analysis. Psychiatry research, 129 (1). pp. 39-44. ISSN 0165-1781 DOI: https://doi.org/10.1016/j.psychres.2004.06.011

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Abstract

Publication bias may exist when nonsignificant findings remain unpublished, thereby artificially inflating the apparent magnitude of an effect. This concern is not new, but it is particularly current in relation to genetic association studies. Data from a recent meta-analysis of association studies of personality were used to assess the potential of different graphical and statistical methods for assessing evidence of publication bias. The results suggest that no single method is sufficient for assessing evidence of publication bias, and that such methods may also offer insight into potential sources of heterogeneity, which may in turn guide the design of future studies.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 15572183
Web of Science ID: 225851500005
URI: http://researchonline.lshtm.ac.uk/id/eprint/4437

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