The relationships between ethnicity, sex, risk group, and virus load in human immunodeficiency virus type 1 antiretroviral-naive patients.


Saul, J; Erwin, J; Sabin, CA; Kulasegaram, R; Peters, BS; (2001) The relationships between ethnicity, sex, risk group, and virus load in human immunodeficiency virus type 1 antiretroviral-naive patients. The Journal of infectious diseases, 183 (10). pp. 1518-21. ISSN 0022-1899 DOI: https://doi.org/10.1086/320191

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Abstract

This cross-sectional study examined the relationships between ethnicity, sex, risk group, and virus load in human immunodeficiency virus type 1 (HIV-1) antiretroviral-naive patients. HIV-1 RNA levels were measured in 322 patients attending St. Thomas' Hospital between May 1997 and February 1999. By univariate analyses, only clinical status and CD4(+) cell count were related to virus load. In multivariate analysis, variables independently related to virus load were CD4(+) cell count (P=.001), being black African (P=.001), having a nonsexual risk for HIV infection (P=.03), and having AIDS (P=.05). Neither sex nor age was a significant predictor of initial virus load after adjusting for other variables. For a given CD4(+) cell count, black Africans and people who contracted HIV nonsexually presented with a virus load lower than that of patients in other groups. Because virus loads may need to be interpreted differently according to ethnicity, this may affect decisions on when to initiate antiretroviral therapy and how to interpret clinical trial results.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 11319688
Web of Science ID: 168284200011
URI: http://researchonline.lshtm.ac.uk/id/eprint/4398

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