[Accepted Manuscript] Six-Year Incidence and Progression of Age-Related Macular Degeneration in Kenya: Nakuru Eye Disease Cohort Study.


Bastawrous, A.; Mathenge, W.; Peto, T.; Shah, N.; Wing, K.; Rono, H.; Weiss, H.A.; Macleod, D.; Foster, A.; Burton, M.; Kuper, H.; (2017) [Accepted Manuscript] Six-Year Incidence and Progression of Age-Related Macular Degeneration in Kenya: Nakuru Eye Disease Cohort Study. JAMA ophthalmology. ISSN 2168-6165 DOI: https://doi.org/10.1001/jamaophthalmol.2017.1109

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Abstract

The incidence of age-related macular degeneration (AMD) is unknown in Africa. To estimate the 6-year cumulative incidence and progression of AMD in older adults (≥50 years old) in Nakuru, Kenya. This study assessed a population-based cohort with 6-year follow-up of 4414 participants who had a complete assessment. Random cluster sampling with probability proportionate to size procedures was used to select a representative, cross-sectional sample of adults 50 years and older from January 26, 2007, through November 11, 2008. A 6-year follow-up was undertaken from January 7, 2013, through March 12, 2014. On both occasions, a comprehensive ophthalmic examination was performed that included logMAR visual acuity, digital retinal photography, and grading of images at Moorfields Eye Hospital Reading Centre. Data were collected on general health and risk factors. Incident AMD in participants with no AMD at baseline and progression from early to late AMD. A total of 1453 of the 2900 individuals (50.1%) at risk for AMD were followed up after 6 years (mean [SD] age, 60.7 [8.2] years; 635 female [49.5%]; 799 Kikuyu [62.3%], 324 Kalenjin [25.3%], and 159 other [12.4%]); 1282 had data on AMD status at follow-up. Of these, 202 developed early AMD, and no participants developed late AMD. The 6-year weighted (for loss to follow-up) cumulative incidence of early AMD was 164.2 per 1000 persons (95% CI, 136.7-195.9 per 1000 persons). Two individuals with baseline early AMD from the 142 at risk had developed late AMD at follow-up, with a 6-year cumulative incidence of progression from early to late AMD of 24.5 per 1000 persons (95% CI, 5.0-111.7 per 1000 persons). Cumulative incidence of AMD increased with age (≥80 years old vs 50-59 years old: 1.8; 95% CI, 0.9-3.5) and was higher in women (female vs male: 1.6; 95% CI, 1.2-2.1) and persons with diabetes (diabetes vs no diabetes: 1.7; 95% CI, 1.0-2.8). In Kenya, more than 100 000 estimated new cases of AMD, mainly early AMD, will develop every year in individuals 50 years or older, although a 50% loss to follow-up and wide CIs for progression to late AMD limit definitive conclusions from these findings.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
URI: http://researchonline.lshtm.ac.uk/id/eprint/4363564

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