Exposure to Farm Animals and Risk of Lung Cancer in the AGRICAN Cohort.


Tual, S; Lemarchand, C; Boulanger, M; Dalphin, JC; Rachet, B; Marcotullio, E; Velten, M; Guizard, AV; Clin, B; Baldi, I; Lebailly, P; (2017) Exposure to Farm Animals and Risk of Lung Cancer in the AGRICAN Cohort. American journal of epidemiology, 186 (4). pp. 463-472. ISSN 0002-9262 DOI: 10.1093/aje/kwx125

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Abstract

: Epidemiologic studies have found lower risks of lung cancer in farmers. However, little is known about the types of agricultural activities concerned. In the Agriculture and Cancer cohort, we assessed the relationship between animal farming and lung cancer by investigating the types of animals, tasks, and timing of exposure. Analyses included 170,834 participants from the Agriculture and Cancer (AGRICAN) cohort in France. Incident lung cancers were identified through linkage with cancer registries from enrollment (2005-2007) to 2011. A Cox model, adjusting for pack-years of cigarette smoking, was used to calculate hazard ratios and 95% confidence intervals. Lung cancer risk was inversely related to duration of exposure to cattle (≥40 years: hazard ratio = 0.60, 95% confidence interval: 0.41, 0.89; P for trend < 0.01) and to horse farming (≥20 years: hazard ratio = 0.64, 95% confidence interval: 0.35, 1.17; P for trend = 0.09), especially for adenocarcinomas, but not with poultry or pig farming. More pronounced decreased risks were reported among individuals who had cared for animals, undertaken milking, and who had been exposed to cattle in infancy. Our study provides strong evidence of an inverse association between lung cancer and cattle and horse farming. Further research is warranted to identify the etiologic protective agents and biological mechanisms.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 28830081
Web of Science ID: 407830300010
URI: http://researchonline.lshtm.ac.uk/id/eprint/4328551

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