Multilocus Sequence Typing (MLST) for Lineage Assignment and High Resolution Diversity Studies in Trypanosoma cruzi.


Yeo, M; Mauricio, IL; Messenger, LA; Lewis, MD; Llewellyn, MS; Acosta, N; Bhattacharyya, T; Diosque, P; Carrasco, HJ; Miles, MA; (2011) Multilocus Sequence Typing (MLST) for Lineage Assignment and High Resolution Diversity Studies in Trypanosoma cruzi. PLoS neglected tropical diseases, 5 (6). e1049. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0001049

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Abstract

Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable genetic and ecological diversity. A standardised MLST protocol that is suitable for assignment of T. cruzi isolates to genetic lineage and for higher resolution diversity studies has not been developed.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 21713026
Web of Science ID: 292139600003
URI: http://researchonline.lshtm.ac.uk/id/eprint/432

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