Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Barrett, JC; Hansoul, S; Nicolae, DL; Cho, JH; Duerr, RH; Rioux, JD; Brant, SR; Silverberg, MS; Taylor, KD; Barmada, MM; Bitton, A; Dassopoulos, T; Datta, LW; Green, T; Griffiths, AM; Kistner, EO; Murtha, MT; Regueiro, MD; Rotter, JI; Schumm, LP; Steinhart, AH; Targan, SR; Xavier, RJ; Libioulle, C; Sandor, C; Lathrop, M; Belaiche, J; Dewit, O; Gut, I; Heath, S; Laukens, D; Mni, M; Rutgeerts, P; van Gossum, A; Zelenika, D; Franchimont, D; Hugot, JP; de Vos, M; Vermeire, S; Louis, E; Cardon, LR; Anderson, CA; Drummond, H; Nimmo, E; Ahmad, T; Prescott, NJ; Onnie, CM; Fisher, SA; Marchini, J; Ghori, J; Bumpstead, S; Gwilliam, R; Tremelling, M; Deloukas, P; Mansfield, J; Jewell, D; Satsangi, J; Mathew, CG; Parkes, M; Georges, M; Daly, MJ; (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet, 40 (8). pp. 955-62. ISSN 1061-4036 DOI:

Full text not available from this repository.


Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

Item Type: Article
Faculty and Department: Distance Learning
Academic Services & Administration > Distance Learning
PubMed ID: 18587394


Download activity - last 12 months
Downloads since deposit
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item