A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population


Prescott, NJ; Fisher, SA; Onnie, C; Pattni, R; Steer, S; Sanderson, J; Forbes, A; Lewis, CM; Mathew, CG; (2005) A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population. Tissue Antigens, 66 (4). pp. 318-20. ISSN 0001-2815 DOI: https://doi.org/10.1111/j.1399-0039.2005.00494.x

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Abstract

A single-nucleotide polymorphism (C1858T) causing an amino acid substitution (R620W) in the lymphoid protein tyrosine phosphatase gene PTPN22 has been implicated in type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, juvenile idiopathic arthritis and Hashimoto's thyroiditis, thus revealing a general role for this gene in autoimmune disease. We investigated the association of the C1858T variant in an additional autoimmune disease population by performing a case-control study of 514 British individuals with inflammatory bowel disease (IBD) [294 with Crohn's disease (CD) and 220 with ulcerative colitis (UC)] and 374 normal controls. No significant differences in genotype or allele frequencies were observed between IBD, CD or UC and controls, indicating that PTPN22 does not influence risk of IBD.

Item Type: Article
Faculty and Department: Distance Learning
Academic Services & Administration > Distance Learning
PubMed ID: 16185328
URI: http://researchonline.lshtm.ac.uk/id/eprint/4269

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